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CALIFORNIA : Hedgehog pathway inhibitors exciting development in treating non-melanoma skin cancer
Meeting a need
In BCNS, or Gorlin syndrome, hundreds of BCCs develop secondary to activation of target genes of the Hedgehog pathway in cells that have lost both normal copies of PTCH.
“Vismodegib has been life-changing for Gorlin patients,” says Jean Y. Tang, M.D., Ph.D., associate professor of dermatology at Stanford School of Medicine in California, who co-led the U.S. Randomized Gorlin Study that tracked a total of 2,000 existing BCCs and followed 694 new BCCs.
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MELBOURNE AUSTRALIA : Oct. 7, 2015 /PRNewswire/ -- Ascend Biopharmaceuticals, a Melbourne-based immunotherapy company focused on developing innovative cancer therapeutics, today announced the first nodular Basal Cell Carcinoma patient (nBCC) dosed with ASN-002 (an injectable immunotherapy) in a Phase 1/2a clinical study. BCC is a type of non-melanoma skin cancer diagnosed in an estimated two million people worldwide every year. It is the most prevalent form of cancer in Australia, the United States and Europe. Surgery is currently the primary treatment for BCC, however for many patients it can be a poor treatment option for both clinical and cosmetic reasons.
Ascend Announces Patients with Nodular Basal Cell Carcinoma Receives First Dose of ASN-002 in Phase 1/2a Study
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Orthomolecular Medicine News Service
Topical Vitamin C Stops Basal Cell Carcinoma
(OMNS) The most common form of skin cancer, basal cell carcinoma, often responds to a remarkably simple, safe, at-home treatment: vitamin C. Physicians and patients report that vitamin C, applied directly to basal cell skin cancers, causes them to scab over and drop off. Successful use involves a highly-concentrated vitamin C solution, directly applied to the blemish two or three times a day. Vitamin C is selectively toxic to cancer cells, but does not harm healthy skin cells. This is also the basis for high-dose intravenous vitamin therapy for cancer. Even higher concentrations of vitamin C can be obtained by direct application. The use of topical vitamin C to kill basal cell carcinoma has been known at least since 1971. Frederick R. Klenner, MD, wrote: "We have removed several small basal cell epithelioma with a 30 percent ointment" of vitamin C.
One person, who reported that a 2mm diameter spot on the nose would not heal for months, had it disappear within a week with twice-daily concentrated vitamin C applications. Another patient reported that after dermatologist-diagnosed multiple spots of basal cell carcinoma were coated with vitamin C, the spots fell off within two weeks.
Basal cell carcinomas are slow growing and it is rare for them to metastasize. This provides an opportunity for a therapeutic trial of vitamin C, provided one has proper medical diagnosis and follow-up.
Preparation of a water-saturated vitamin C solution is simple. Slowly add a small amount of water to about half a teaspoon of vitamin C powder or crystals. Use just enough water to dissolve the vitamin C. Using less water will make a paste. Either way, application with the fingertip or a cotton swab, several times daily, is easy. The water will evaporate in a few minutes and leave a plainly visible coat of vitamin C crystals on the skin.
Consult your doctor before employing this or any other self-care treatment. A physician’s diagnosis is especially important, since other forms of skin cancer, such as melanoma, are faster growing and more dangerous. If the vitamin C treated area is not improved after a few weeks, a doctor should be consulted once again.
References:
[1] William Wassell, MD: Skin cancer and vitamin C. Cancer Tutor, http://www.cancertutor.com/Cancer02/VitaminC.html
[2] Riordan NH, Riordan HD, Meng X, Li Y, Jackson JA: Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Med Hypotheses 1995; 44: 207-2 13. http://www.brightspot.org/cresearch/intravenousc2.shtml and http://www.seanet.com/~alexs/ascorbate/199x/riordan-nh-etal-med_hypotheses_1995-v44-p207.htm and also http://www.doctoryourself.com/riordan1.html
[3] Fredrick R. Klenner, MD: Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology. Journal of Applied Nutrition Vol. 23, Nos 3 & 4, Winter 1971. http://yost.com/health/klenner/klenner-1971.pdf and http://www.doctoryourself.com/klennerpaper.html
[4] Age spots, basal cell carcinoma and solar keratosis. http://www.doctoryourself.com/news/v5n9.txt
Nutritional Medicine is Orthomolecular Medicine
Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org
The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.
Editorial Review Board:
Carolyn Dean, M.D., N.D.
Damien Downing, M.D.
Harold D. Foster, Ph.D.
Steve Hickey, Ph.D.
Abram Hoffer, M.D., Ph.D.
Thomas Levy, M.D., J.D.
Erik Paterson, M.D.
Bradford Weeks, M.D.
Andrew W. Saul, Ph.D., Editor and contact person. Email: omns@orthomolecular.org This article may be reprinted free of charge provided 1) that there is clear attribution to the Orthomolecular Medicine News Service, and 2) that both the OMNS free subscription link http://orthomolecular.org/subscribe.html and also the OMNS archive link http://orthomolecular.org/resources/omns/index.shtml are included.
Orthomolecular Medicine News Service
Topical Vitamin C Stops Basal Cell Carcinoma
(OMNS) The most common form of skin cancer, basal cell carcinoma, often responds to a remarkably simple, safe, at-home treatment: vitamin C. Physicians and patients report that vitamin C, applied directly to basal cell skin cancers, causes them to scab over and drop off. Successful use involves a highly-concentrated vitamin C solution, directly applied to the blemish two or three times a day. Vitamin C is selectively toxic to cancer cells, but does not harm healthy skin cells. This is also the basis for high-dose intravenous vitamin therapy for cancer. Even higher concentrations of vitamin C can be obtained by direct application. The use of topical vitamin C to kill basal cell carcinoma has been known at least since 1971. Frederick R. Klenner, MD, wrote: "We have removed several small basal cell epithelioma with a 30 percent ointment" of vitamin C.
One person, who reported that a 2mm diameter spot on the nose would not heal for months, had it disappear within a week with twice-daily concentrated vitamin C applications. Another patient reported that after dermatologist-diagnosed multiple spots of basal cell carcinoma were coated with vitamin C, the spots fell off within two weeks.
Basal cell carcinomas are slow growing and it is rare for them to metastasize. This provides an opportunity for a therapeutic trial of vitamin C, provided one has proper medical diagnosis and follow-up.
Preparation of a water-saturated vitamin C solution is simple. Slowly add a small amount of water to about half a teaspoon of vitamin C powder or crystals. Use just enough water to dissolve the vitamin C. Using less water will make a paste. Either way, application with the fingertip or a cotton swab, several times daily, is easy. The water will evaporate in a few minutes and leave a plainly visible coat of vitamin C crystals on the skin.
Consult your doctor before employing this or any other self-care treatment. A physician’s diagnosis is especially important, since other forms of skin cancer, such as melanoma, are faster growing and more dangerous. If the vitamin C treated area is not improved after a few weeks, a doctor should be consulted once again.
References:
[1] William Wassell, MD: Skin cancer and vitamin C. Cancer Tutor, http://www.cancertutor.com/Cancer02/VitaminC.html
[2] Riordan NH, Riordan HD, Meng X, Li Y, Jackson JA: Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Med Hypotheses 1995; 44: 207-2 13. http://www.brightspot.org/cresearch/intravenousc2.shtml and http://www.seanet.com/~alexs/ascorbate/199x/riordan-nh-etal-med_hypotheses_1995-v44-p207.htm and also http://www.doctoryourself.com/riordan1.html
[3] Fredrick R. Klenner, MD: Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology. Journal of Applied Nutrition Vol. 23, Nos 3 & 4, Winter 1971. http://yost.com/health/klenner/klenner-1971.pdf and http://www.doctoryourself.com/klennerpaper.html
[4] Age spots, basal cell carcinoma and solar keratosis. http://www.doctoryourself.com/news/v5n9.txt
Nutritional Medicine is Orthomolecular Medicine
Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org
The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.
Editorial Review Board:
Carolyn Dean, M.D., N.D.
Damien Downing, M.D.
Harold D. Foster, Ph.D.
Steve Hickey, Ph.D.
Abram Hoffer, M.D., Ph.D.
Thomas Levy, M.D., J.D.
Erik Paterson, M.D.
Bradford Weeks, M.D.
Andrew W. Saul, Ph.D., Editor and contact person. Email: omns@orthomolecular.org This article may be reprinted free of charge provided 1) that there is clear attribution to the Orthomolecular Medicine News Service, and 2) that both the OMNS free subscription link http://orthomolecular.org/subscribe.html and also the OMNS archive link http://orthomolecular.org/resources/omns/index.shtml are included.
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